In this video, I present the recent insights into knee osteoarthritiss.
Knee osteoarthritis has mechanical and inflammatory causes. There is a low-grade inflammation caused by the breakdown products of cartilage. There is also an immunogenic cause. Platelet-rich stroma and Platelet-rich plasma contain anti-inflammatory and regenerative substances that ameliorate the symptoms of osteo-arthritis. Platelet-rich stroma is a combination of Stromal vascular fraction (SVF) and PRP/
Stromal vascular fraction (SVF) has been suggested as a potential treatment for knee osteoarthritis due to its ability to combat the inflammatory causes of the condition. SVF contains a mixture of various cells, including mesenchymal stem cells (MSCs), immune cells, and other regenerative cells, which work together to address inflammation and promote tissue healing.
- Anti-inflammatory properties: MSCs within SVF have been found to possess anti-inflammatory properties. They can modulate the immune response and reduce the production of pro-inflammatory molecules, such as cytokines and chemokines. By suppressing inflammation, SVF can help alleviate pain and reduce the progression of knee osteoarthritis.
- Immune modulation: SVF contains immune cells, including regulatory T cells (Tregs), which play a role in immune regulation. Tregs can suppress the activity of other immune cells that contribute to inflammation. This immune modulation by SVF can help control the inflammatory response in the knee joint affected by osteoarthritis.
- Growth factor secretion: SVF cells, including MSCs, have the ability to secrete various growth factors, which can aid in tissue repair and regeneration. These growth factors promote the proliferation and differentiation of cells involved in cartilage and tissue repair, contributing to the healing process in the knee joint affected by osteoarthritis.
- Paracrine effects: SVF cells secrete factors that exert paracrine effects, meaning they influence nearby cells. These paracrine factors can have anti-inflammatory effects and promote tissue regeneration, helping to combat the inflammatory causes of knee osteoarthritis.
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