-
Knee arthritis is often described as a “wear and tear” condition, but modern research shows a deeper and far more important mechanism: metabolic inflammation inside the joint. Factors such as high glucose load, oxidative stress, mitochondrial dysfunction, and the accumulation of advanced glycation end-products can silently damage cartilage long before X-rays show any narrowing. This metabolic injury also sensitizes nerve endings, increases fat pad inflammation, and accelerates joint degeneration in ways that traditional explanations cannot fully capture.
- For patients in Chennai, this distinction matters. When we correctly identify metabolic drivers, we can design more effective biologic treatments, optimize PRASAD protocols, and select interventions that help the joint heal rather than merely cope with symptoms.
To understand this mechanism clearly — with diagrams, explanations, and practical implications for treatment — I have created a complete article on my primary orthobiologics website.
- 👉 Read the full article here : https://orthobiologicsurgeryindia.com/its-not-just-wear-and-tear-the-metabolic-secret-behind-your-chronic-knee-pain/
- Metabolic Basis of Knee Arthritis
- www.orthobiologicsurgeryindia.com
- This in-depth version covers pathways, clinical relevance, and how metabolic reprogramming is integrated into the Madras Rejuvenation Centre’s regenerative protocols.
This article is part of our evidence-based joint education series at the Madras Rejuvenation Centre.